Endocrine Abstracts

Introduction: Adrenocortical carcinoma (ACC) is a very rare neoplasm with an incidence of about one case per million population. It is an agressive tumor (overall 5-year survival 16–38%) and complete resection is the only curative treatment.Description of methods: We report four cases of ACC. The clinical and biochemical features at diagnosis along with clinical course of the disease are discussed.Results: Four patients (three...

Background: High prevalence of hypovitaminosis D in diabetic patients has been reported and has been associated with microvascular complications and insulin treatment in type 2 diabetic patients.Methods: Observational study in 92 inhospital patients with different types of diabetes. We analyzed the relationship between serum 25-hydroxyvitamin D (25-OHD) concentration and the clinical features associated with diabetes.Results: Of 36...

Introduction: Neonatal diabetes mellitus is a rare form of diabetes, diagnosed within the first six months of life. We report a case of a 24-year-old patient with permanent neonatal diabetes.Case Report: The patient had no relevant family history. Her mother had no gestational diabetes. Personal history included: Normal birth weight, polycystic ovarian syndrome and ovarian teratomas. She was diagnosed of diabetes at 3 months of age, starting immediately ...

Introduction: MODY 5 is a rare type of dominantly inherited diabetes mellitus. It is asociated with mutations of the hepatocyte nuclear factor-1beta (HNF-1beta) gene. They are mostly missense mutations that produce truncated proteins with a variable clinical spectrum that encompasses among others: kidney, genital and pancreatic abnormalities.Case-report: A 35 years-old man without relevant medical history, presented with acute hypergycemia (541 mg/dl) an...

Introduction: Evaluation of postmenopausal hyperandrogenism may be a challenge for physicians as it is necessary to exclude the presence of the relatively rare but potentially life-threatening underlying tumorous causes. We report the case of a postmenopausal woman who presented with clinical and biochemical hyperandrogenism.Case Report: We present the case of a 65 year-old woman being followed at our clinic because of mild hypothyroidism. At inspection ...

Introduction: Roux-en-Y gastric bypass (RYGB) places patients at an increased risk of hypocalcemia due to the reduction in calcium absorption (because the procedure bypasses the duodenum and jejunum) and vitamin D deficiency. Subsequent thyroid surgery increases the risk of severe hypocalcemia due to potential post-operative hypoparathyroidism. Only a few cases have been published before of this kind of treatment-challenging hypocalcaemia.Case report: We...

Introduction: Diabetes mellitus is a condition on the increase, carrying a high risk of macro and microvascular disease. Previous studies suggest a link between microvascular and macrovascular complications in diabetes. However, just a few studies have investigated whether the presence of peripheral vascular disease (PVD) is associated with other macrovascular and microvascular complications in diabetes patients. So, this was the aim of our study.Patient...

Introduction: It is well known that diabetes confers a substantial burden of macrovascular disease. However, just a few studies have investigated the association between diabetic kidney disease (DKD) and cardiovascular disease. The purpose of this study is to investigate whether the presence of DKD is associated with macrovascular disease in diabetic patients.Patients and methods: 98 diabetic patients (48 males/50 females) were included in the study. DKD...

Risk factors involved in new-onset diabetes mellitus after transplantation (NODAT) remain unclear. Clinical studies have demonstrated the association between low vitamin D levels with insulin resistance and diabetes. In animal models, osteocalcin deficiency leads to high glucose levels and insulin resistance.The aim of this study is to evaluate the prevalence of NODAT and other alterations of glucose metabolism after liver transplantation (LT) at our ins...

Introduction: Currently self-glycemic control by the patient is essential to achieve a right metabolic control of diabetes. Nowadays, there are different systems that have proved useful for this aim.Objectives: Valuing any possible differences between systems and the relation with glycemia identified in our laboratory.Material and methods: We took blood samples by vein-puncture to 41 patients, and simultaneously we measured capilla...